Biological Safety Principles and Practices, 4th Edition by Fleming and Hunt

Bibliographic Information:
Title: Biological Safety Principles and Practices
Editor: Diane O. Fleming,
Debra L. Hunt
Edition: 4th
Publisher: ASM Press
Length: 642 pages
Size: 6.47 MB
Language: English

PRACTICES consists of 33 chapters from over 50 authors with many
decades of experience in biological safety. We especially appreciate
the additional effort of seven of these authors who also served as
Section Editors. Fifteen new authors provide fresh insight on biological
toxins, packaging and shipping, biological safety program management,
Occupational Medicine in a biomedical research setting, safety
considerations in the BSL-4 maximum containment laboratory, and
special considerations for agriculture pathogens. All of the other chapters
have been appropriately updated. For example, the prion chapter
underwent major changes to address the transmission of variant
Creutzfeldt-Jakob disease via blood transfusion, which occurred since
the previous edition. Of special significance are chapter 4, “Epidemiology
of Laboratory-Associated Infections,” and chapter 7, “Protozoa and
Helminths,” both of which contain previously unreported cases and
reviews of previous surveys.
Since the third edition of this book, untoward events, such as the
anthrax letters in 2002, have had an impact on the field of biosafety and
those who work with microbial agents. Regulations have been broadened
to prevent terrorists from obtaining certain microbes believed to
be useful as biological weapons. These Select Agent regulations from
the Centers for Disease Control and Prevention (CDC) and from the
United States Department of Agriculture include stringent requirements
to limit those who can obtain, store, or use these agents. Such
individuals must undergo a security check, including fingerprinting,
and receive a clearance from the Department of Justice. Biosafety personnel
now have the additional duty of implementing key biosecurity
sections of this regulation. Chapter 33 provides a discussion of the
impact of regulations on biosafety and biosecurity.
One of the features of previous editions of this book has been the
inclusion of the actual regulation from the Occupational Safety and
Health Administration (OSHA), the National Institutes of Health
(NIH) guidelines, and the CDC/NIH guidelines “Biosafety in
Microbiological and Biomedical Laboratories” (BMBL). Unfortunately,
the 5th edition of BMBL is still in press, with no clear date of publication.
Since all of the documents are available on the Internet, we refer
the reader to those sources instead.
This book is meant to be used as a resource by biosafety professionals,
those who teach them, and those who work with pathogenic agents
in research, production, or teaching. We have included what is known
to be important today. However, biotechnology breakthroughs, such as
nanotechnology and synthetic genomics, can be expected to challenge
our ability to do appropriate risk assessments in the future. In the six
years since the previous edition, poliovirus was synthesized by using a
map of the genome which was published in the literature. The synthesis
of any virus from its genetic map has become a reality. Will our
efforts to recognize and assess the potentially unrecognizable hazards
that could arise from combining pieces of many synthesized viruses
allow us to continue to find effective methods of containment? Such
challenges require that we continuously strive to share information
gathered in the broad scope of biological research. We hope this book
will aid in this endeavor.

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